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KMID : 0359319980380020379
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Korean Journal of Veterinary Research
1998 Volume.38 No. 2 p.379 ~ p.385
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Diethylnitrosamine - induced hepatic tumorigenesis in rats
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Kim Chang-Hwan
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Abstract
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The study was designated to investigate the gross findings following treatment with diethylnitrosamine (DEN) in rats. Forty four male rats (Sprague Dawley), initially 5 to 6 weeks of age and 120 to 150gm in body weight were continuously given water containing 0.01% DEN for 13 weeks and 3-6 rats per week were randomly sacrified at intervals of a week from 8 weeks to 17 weeks.
The numbers of rats died until 17 weeks were 11 rats and first death occurred at 10 weeks.
Body, liver and spleen weights were weighed and the relative weight levels of the liver and spleen per body weights were increased from 4.4% and 0.5% at control groups to 15.1% and 1.1% at 17 weeks.
The numbers of RBC were not varied but PCV were decreased from 44.5% in control group to 27.5% in 16 weeks.
A few of greyish-white foci or nodules of tumors were developed or not on the surfaces of the livers at 8 weeks but were developed on all livers after 9 weeks.
The diameter of the largest tumor from all rat livers was 35.8 ㎜ at 12 weeks.
The numbers of developed tumors per a rat liver were appeared to be about 20 in 13 weeks and about 50∼60 in 17 weeks.
The diameter of some larger tumors were found to be 3∼9㎜ in 13 weeks and 7∼15㎜ in 17 weeks and more number of tumors were developed in the visceral surfaces than in the diaphragmatic surfaces of the livers. The parenchymae of livers were fragility.
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